Journal of Ayurveda and Holistic Medicine (JAHM)

A Comprehensive Comparative Study of Five Medicinal Vitex Species Using Physicochemical, Phytochemical, HPTLC and FTIR Analyses

2025-05-19T11:26:47+00:00

Background: This study aims to perform a comparative analytical evaluation of five Vitex species—Vitex agnus-castus, V. cannabifolia, V. negundo, V. ovata, and V. trifolia—to identify their similarities and differences. While V. negundo is the accepted source of Nirgundi, a key Ayurvedic herb for inflammation management, other species are also used under this name. The findings will aid in assessing their therapeutic equivalence and support the rational use of Vitex species in Ayurvedic formulations.

Materials and Methods: Leaves of five Vitex species were collected, authenticated, and subjected to physicochemical analysis (loss on drying, ash value, extractive value) and qualitative phytochemical screening as per API standards. HPTLC was performed using the method given by HPTLC association. FTIR analysis was carried out using UATR.

Results: Physicochemical analysis showed variations in loss on drying, ash, and extractive values among Vitex species compared to V. negundo. Phytochemical screening confirmed alkaloids, flavonoids, and phenolics in all species. HPTLC provided distinct fingerprints with shared bands, while FTIR revealed characteristic hydroxyl, carbonyl, and aromatic groups, highlighting chemical similarities and differences.

Conclusion: This study compares five Vitex species, emphasizing their potential interchangeability and therapeutic relevance. Analytical tools like HPTLC and FTIR ensure herbal drug quality, efficacy, and standardization. The findings support sustainable use of alternative species, reducing reliance on Vitex negundo and promoting resource conservation in Ayurvedic formulations.

Exploring Quinovic Acid as a potential lung cancer therapy: Insights from network pharmacology and molecular docking

2025-05-20T00:14:33+00:00

Background: Lung cancer is the predominant cause of cancer-related death globally, attributed to delayed diagnosis and limited therapeutic effectiveness. Natural chemicals provide potential avenues for the development of innovative cancer therapeutics. Objective: This study seeks to investigate the anticancer efficacy of quinovic acid in lung cancer via a network pharmacology approach combined with molecular docking techniques. Methods: A network pharmacology analysis was conducted to discover the proteins targeted by Quinovic acid. The targets were also analysed for potential overlap with genes linked to lung cancer. A Protein-Protein Interaction (PPI) network was constructed to identify pivotal hub genes. Molecular docking simulations were conducted to evaluate the binding affinity of quinovic acid with the indicated targets. Results: Network pharmacology indicates that quinovic acid interacts with a diverse array of proteins, predominantly phosphatases (33.3%) and phosphodiesterases (26.7%). A substantial overlap of 49 genes was identified between quinovic acid targets and lung cancer-associated genes, suggesting potential therapeutic relevance. PPI analysis identified essential hub genes including TP53, EGFR, KRAS, BRAF, and PIK3CA, which are involved in significant signalling pathways such as PI3K-AKT, MAPK, and apoptosis. Computer-simulated ligand binding analyses demonstrated substantial binding affinities of quinovic acid, particularly with BRAF and PIK3CA (-9.2 kcal/mol). Conclusion: The results indicate that quinovic acid may inhibit cancer proliferation by altering many critical oncogenic pathways, rendering it a promising option for lung cancer treatment. Additional experimental validation is necessary to demonstrate its therapeutic effectiveness.

A Pharmaceutico-analytical investigation of Rajat Bhasma synthesized through modified techniques employing mercurial compounds

2025-05-20T00:10:30+00:00

Background: The quality of metal Bhasma and the number of Puta (specific quantum of heat) required for its preparation depends on the raw materials used. Mercury and its compounds are considered superior for producing metallic Bhasma, which can be applied in the form of an amalgam with metal or as a paste over metal foil. Aim: To evaluate the impact of equal quantities of mercury and sulfur in paste form on Bhasma preparation and to compare the results with those of previous studies. Methodology: Rajat Bhasma (RB) was prepared using equal quantity of Shuddha Parad (processed mercury) with Shuddha Gandhak (processed sulphur) in every Puta and in the paste form in the first Puta. Rajat Bhasma was analysed for ancient Bhasma Praiksha (tests), its physicochemical parameters, elemental analysis through XRF, crystal study through XRD, and particle size through dynamic light scattering (DLS). Results: Three Puta were required to prepare an RB that passed all ancient parameters. RB contained 17.7 % silver, 30.7 % mercury, and 50.8 % sulfur. The XRD study showed peaks of silver sulfide in the RB. RB contains particles in the range–300-400 nanometres. Conclusion: Adopting the use of Kajjali in the first Puta and an equal quantity of mercury and sulphur in the remaining Puta’s reduces the number of Puta’s required to three. This also resulted in and percentage of silver, mercury, and sulfur in the final RB.

Exploring physio-anatomical similarities between the Muladhara Chakra and the inferior hypogastric plexus: Evidence from a cadaveric study

2025-05-19T23:30:43+00:00

Background:
The concept of Chakras, particularly the Muladhara Chakra, is well-established in yogic and tantric literature. Traditionally described as an energy center located at the base of the spine, the Muladhara Chakra is associated with physiological functions such as excretion, reproduction, and foundational vitality. Despite extensive spiritual interpretations, limited attempts have been made to correlate its anatomical basis using modern science.

Objective:
This study aims to identify the anatomical equivalent of the Muladhara Chakra, with a specific focus on its correlation with the inferior hypogastric plexus and its sub-plexuses.

Materials and Methods:
A comprehensive review of classical tantric literature and modern anatomical texts was undertaken. Additionally, dissection of six cadavers was conducted at the Department of Sharira Rachana, Govt. Ay. College & Hospital, Patna. Anatomical landmarks corresponding to the traditional location of the Muladhara Chakra were identified, followed by detailed superficial and deep dissections. Observations were compared with descriptions found in both ancient scriptures and contemporary literature.

Results:
The anatomical location and triangular configuration of the inferior hypogastric plexus closely resemble descriptions of the Muladhara Chakra. The four petals (Dalas) of the Chakra—Vama, Sama, Shama, and Shhama—were found to align with four major pelvic sub-plexuses: the uterine, vaginal (or seminal), vesical, and middle rectal plexuses. This supports the hypothesis that the inferior hypogastric plexus serves as the anatomical basis for the Muladhara Chakra.

Conclusion:
The study provides a scientific perspective on the anatomical identity of the Muladhara Chakra, correlating it with the inferior hypogastric plexus and its four subdivisions. While these findings offer a new layer of anatomical understanding to ancient yogic knowledge, further multidisciplinary studies are recommended to explore other attributes and functional aspects of the Chakra.

Critical Analysis of MS Arogyalavana in Comparison with Rasendra Chudamani

2025-05-21T20:57:19+00:00

Background: The art of writing emerged as a way of preserving knowledge that was previously transmitted orally from one generation to the next though recording thoughts and ideas, it became possible to transmit knowledge not only to the future generations but also distant land. Manuscript, which means 'written by hand', is a recording of information created by someone at some time. Sanskrit was the most popular medium of instruction for a long time. The primary aim of the manuscripts was to preserve knowledge. Arogyalavana is untouched MSS (Manuscripts) present in oriental institute of Baroda, it is a single folded sheet with 2 folios. Aim & objectives: To study MS (Manuscript) Arogyalavana & Compare the formulations in MS with formulations in Rasendra chudamani (Ras.ch). Methodology- Unpublished MS Arogyalavana is collected from Oriental Institute Baroda. Formulations in the MS compared with Rasendra chudamani (Ras.ch). Observation: In this Manuscript Two Kalpas are given out of which first one is Arogyalavana & other 4 Kaplas are Kshar Kaplana. In this contents, Preparatory method, Anupana & Indications are given. Conclusion: This MS Arogyalavana includes Preparatory method, Anupana and uses. It is a collection of more Kalpas with preparatory methods, indications. Formulations like Arogyalavana and other should be further studied and clinically explored to see its efficiency. MS like this are treasure house of knowledge and should be explored for further studies.

The Role of Yoga in Addressing Psychosocial Challenges Among Institutionalized Orphans: A Narrative Review

2025-05-21T13:15:53+00:00

Institutionalized orphans face profound psychosocial challenges, including anxiety, depression, and post-traumatic stress disorder (PTSD), due to early adversity and chronic stress. This narrative review examines the role of yoga as a therapeutic intervention for this vulnerable population. A comprehensive search of PubMed/MEDLINE, PsycINFO, Cochrane Library, Scopus, and Google Scholar yielded 27 studies (15 randomized controlled trials, 8 quasi-experimental studies, 4 qualitative) conducted across Asia, Africa, Eastern Europe, and Latin America. Results indicated consistent reductions in anxiety (median Cohen’s d = 0.71), depression (d = 0.65), and PTSD symptoms (d = 0.82), alongside improved social connectivity and physiological stress regulation (22% cortisol reduction). Trauma-sensitive yoga programs demonstrated particular efficacy, with culturally adapted interventions showing higher retention rates (88%) compared to standardized protocols, though secular settings sometimes required modifications to avoid religious symbolism. Mechanisms of action aligned with the biopsychosocial model, highlighting yoga’s capacity to modulate neurobiological stress responses, enhance emotional regulation, and foster peer trust through group-based practices. However, heterogeneity in outcome measures, short follow-up durations, and limited evidence on attachment-related outcomes underscore the need for methodologically robust, longitudinal studies. The findings advocate for integrating culturally adapted yoga into orphan care policies as a scalable, non-stigmatizing adjunct to conventional mental health services. Further research should explore hybrid models combining yoga with attachment-focused therapies and evaluate long-term developmental impacts to optimize resilience in this marginalized population.

Revitalizing the Gurukul System in Medical Education- A review

2025-05-17T16:54:22+00:00

Background:

The concept of modern mentoring and the conventional gurukul system has played a vital role in education, particularly in ancient India. Both of these systems emphasize personal guidance, deep learning, and holistic development. The gurukul system of education was an ancient Indian educational tradition, where students (shishyas) would live with their teachers (gurus) in an ashram to learn various aspects of life, knowledge, and spirituality. Mentoring system was deeply embedded in the culture, and the mentorship aspect played a vital role in the shaping of individuals and communities. In the modern times, there has been a growing recognition of the need to bring back elements of the gurukul system, particularly in mentoring, to help individuals reach their full potential in education and career. The review aimed to assess the revitalization of the old Gurukul system as Modern Mentoring system.

Methods: Articles published in the past 10 years were chosen from various databases such as PubMed, Scopus, Web of Science, Google Scholar etc with keywords Gurukul, Sishya, menoring, mentor and mentee. The information obtained were compiled.

Discussion and conclusion: The mentoring aspect of the gurukul system, which involved a close personal guidance, life lessons, and learning beyond books, holds significant value in today's world. Mentoring plays a critical role in personal and professional development, offering guidance, support, and encouragement. Without mentoring, individuals, particularly those in the early stages of their careers or life, may face a range of challenges. This narrative review has been undertaken to bring back the importance of mentoring or gurukul system in bringing out effective outcomes in modern medical education.

Exploration of Indravasti marma through hermeneutic research methodology

2025-06-05T07:28:18+00:00

Background: Ayurvedic treaties have explained 107 marma points in the human body. Exploration of the underlying anatomical structures gives insight in to the marma point, but it only adds up to a small portion the of total information and due to the same reason, many aspects of the marma shastra still remain as an enigma. Aim and objectives: to execute a hermeneutic study of the Indravasti marma. Methodology: Indravasti Marma, a vital point in Ayurvedic marma sastra, is explored through a hermeneutic study. It combines anatomical, physiological, philological, and historical analyses. Results: Indravasti Marma, classified as a mamsa marma (muscle-based marma), is located in the mid-foreleg and forearm regions. Despite being a mamsa marma, injury to this marma leads to significant hemorrhage, suggesting the involvement of underlying vascular structures. Such as the posterior tibial and radial arteries. This apparent contradiction is addressed through hermeneutic analysis, where the term "Indravasti" is broken down into "Indra" and "Vasti". Among others indra has a less popular meaning red as in the term ‘indragopa’ (red-bug), and vasti means bladder. This clarifies the intention of the acharyas to give emphasis to both musculature and vasculature. Conclusion: This methodology provides comprehensive understanding of Indravasti Marma, highlighting the need to integrate ancient Ayurvedic knowledge with modern anatomical and physiological insights.

Pediatric Drug Regulation in Ayurveda: Current Gaps and Strategic Solutions

2025-05-27T06:29:54+00:00

Pediatric Drug Regulation in Ayurveda: Current Gaps and Strategic Solutions

Impact of eating habits in adolescent obesity-A case control study

2025-06-07T06:48:26+00:00

INTRODUCTION: Obesity refers to increased adiposity in the body. Obesity in children gained the status of epidemics in recent years. It is an issue of concern even in developing countries like India owing to swift economic transition, lifestyle changes and globalization of food. Obesity children and adolescents may persist in later life and can be mapped to childhood onset metabolic syndromes and non-communicable disorders. This study aimed at assessing impact of eating habits in adolescents on obesity. Thus, early identification of obesity in children and interventions can pave way for healthier community.

Methods: A case control study was conducted in 111 obese and 488 non-obese adolescent high school children aged between 14 to 17 years. Body mass index (BMI) was used assess and children with BMI >30 were considered as obese (WHO). The data was collected using a structured case report form (CRF) incorporating food frequency index and the data set was analyzed using MS office Excel and SPSS soft ware version 20.

Results: Prevalence of obesity was 18.5% in high school children. The prevalence was more in higher grade students, upper middle class and females were more affected. Butter was major dietary risk factor. Higher intake of calorie dense, fatty, sugar foods like laddu (p ≈ 0.019), jalebi (p ≈ 0.011), and kajukatli (p ≈ 0.013) and Ice cream (p ≈ 0.00003) was associated with obesity. Conclusion: obesity prevalence alarmingly increased. There is an urgent need to educate parents and children dietary habits and impact of adolescent obesity on health through intensive community health campaigns through all effective media with an emphasis on preventive strategies.

Key words: adolescent, BMI, food frequency index, obesity, school children

Adverse drug reaction following the concurrent use of alcohol and Ayurvedic formulation Sahacharadi Avartita Taila: A case report

2025-05-02T13:35:13+00:00

Background: Adverse drug reactions (ADRs) are uncommon but can cause significant complications in Ayurvedic therapies, especially when lifestyle factors are considered. Sahacharadi Avartita Taila used for managing musculoskeletal disorders was used for snehapana (internal oleation). Case Report: A 56-year-old male diagnosed with a condition similar to lumbar disc degeneration presented with radiating low back pain and numbness. He was admitted to the hospital on 12th October 2023 and treatment started by Shamana Snehapana with 10 drops of Sahacharadi Avartita Taila in milk daily. He developed acute inflammatory cellulitis on his face and required emergency hospital care on 4^th day. Results: The medication was immediately stopped and a clinical review was done which revealed that the patient was consuming alcohol during the course of treatment, which was brought to our attention by a bystander. The patient had initially concealed his history of alcohol use. The development of cellulitis must have happened due to the intake of alcohol which interacted adversely with the Snehapana. Gradual recovery happened with administration of Intensive treatment. Conclusion: This case of Adverse Drug Reaction Following the intake of Alcohol and Shamana Snehapana emphasizes the importance of adhering to dietary and lifestyle guidelines as advised by the consultant during intake of Snehapana. The adverse reaction was likely due to alcohol consumption which was an important contraindication that the patient concealed and the seasonal influence of summer further aggravated the condition. This case highlights the need for thorough patient education regarding treatment protocols and contraindications. Ensuring compliance with classical guidelines and standard operative procedures is essential to prevent such adverse events and to safeguard patient outcomes.

Fetal Growth Restriction: Ayurveda Treatment for Optimizing Fetal Growth – A Case Report

2025-05-08T23:29:44+00:00

Fetal growth restriction (FGR) is a significant complication in pregnancy, leading to increased perinatal morbidity and mortality. In Ayurveda, FGR is described as Garbhashosha or Vatabhipanna Garbha, characterized by as Akukshi Poorana (Uterine size smaller than expected for gestational age) and Manda Garbha Spandana (Reduced fetal movements), often caused by imbalances in Matruja Rasa Dhatu and Vata Dosha. A 27-year-old primigravida at 31weeks 4 days of gestation presented for a routine antenatal check-up. She reported normal perception of fetal movements and had no active complaints. Clinically, she exhibited mild pallor and a fundal height smaller than expected for her gestational age, suggesting potential FGR. Ultrasonography confirmed the FGR. The patient was treated with Brihmana Chikitsa including Ksheera Basti, Matra Basti and oral medications aimed at nourishing the Matruja Rasa Dhatu and balancing Vata Dosha to support the fetal growth. Significant improvement was observed in fetal growth as evidenced by an increase in estimated fetal weight and improved fetal biometry and a normal doppler study.

Ayurvedic approach to the management of Dry Gangrene (Vrana Kotha) In Peripheral Vascular Disease: A case report

2025-04-27T22:54:47+00:00

Peripheral vascular disease (PVD) presents a significant challenge for surgeons, often culminating in the development of dry gangrene. The prevalence of dry gangrene resulting from peripheral vascular disease is notably higher in populations under the age of 45 with a history of tobacco or smoking use. A study indicates that gangrene affects 0-5% of the Indian population, with the majority of cases occurring in individuals aged 20-40.[1] Ayurveda, addresses peripheral vascular disease and dry gangrene, drawing correlations with the concept of Vrana Kotha. Management of dry gangrene encompasses local and systemic approaches, including Vrana Shodhana, Vrana Ropana, and oral medications. [2]

A 38-year-old male, non-diabetic and non-hypertensive, sought treatment at Shalya Tantra IPD for wounds on his toes accompanied by pain, burning sensation, discolouration, and discharge. A chronic smoker for 23 years, he had no known metabolic or systemic disorders. We developed a comprehensive Ayurvedic management plan incorporating local and systemic interventions. Throughout the treatment course, the patient exhibited notable improvement, with reduced pain and visible healing of the gangrenous tissue. Subsequent assessments revealed restored circulation and stabilization of the affected area.

Integrated Ayurvedic and Physiotherapy approach in the management of acute lateral ankle sprain- A Case Report

2025-05-21T12:30:55+00:00

Background: Ankle sprains are the most frequent musculoskeletal injuries, often leading to functional instability and temporary impairment. The "RICE’ protocol is commonly practised for early recovery. The management principles in Ayurveda can be understood under Bhagna Chikitsa, Sadyovrana, and Marma chikitsa. Integration of two systems is the need of the hour for better treatment outcome and quality patient care. Clinical findings: A 26-year-old young male student, presented with swelling and pain at the right ankle joint since the last 24 hours, which was associated with difficulty and increased pain while walking. The case was diagnosed as a right-sided lateral ankle sprain by performing a talar tilt test and an anterior drawer test, which showed positive signs. Ottawa ankle rules were performed to differentiate it from fractures by advising an X-ray of the foot with anteroposterior, lateral, and oblique views, which was normal in this case. Outcome: The adopted integrated treatment, which includes local Ayurvedic procedures, standard RICE protocols, and physiotherapy procedures, gave good results in the form of pain reduction, swelling, local temperature, increased range of motion, and an early return to sports. Conclusion: Integrated treatment approach for a period of 2 months has given good outcome with no adverse events. The patient has returned to play and performing well, further research in this area is necessary to validate the results.

Ayurvedic Insights into SRUS: A Holistic Approach to Solitary Rectal Ulcer Syndrome - A Case Report

2025-04-28T00:00:44+00:00

Solitary Rectal Ulcer Syndrome (SRUS) is a multifaceted rare gastrointestinal disorder characterized by the development of solitary or multiple ulcers in the rectum. This condition often presents with chronic constipation, rectal bleeding, and pain, significantly impacting the quality of life. The pathophysiology of SRUS is intricate, involving interplay between mechanical, inflammatory, and psychological factors. Accurate diagnosis requires a thorough diagnostic process that includes colonoscopy, histopathology, and clinical examination. A multidisciplinary approach is needed to manage SRUS, involving behavioural therapy, medication, and dietary changes. With a focus on its intricate pathophysiology, diagnostic difficulties, and ayurvedic therapeutic options, we hope to present a clear overview of the current knowledge of SRUS in Ayurveda as Abyantara dusta vrana (Internal Ulcers) associated with Parikartika (Fissure in Ano).

Determining geo-ecological parameters for designing Desha wise map of Belgaum district and assessment of Prakriti predominance - A cross sectional study

2025-05-08T17:17:04+00:00

Introduction: In clinical practice, Bhumi Desha, or a person's geographical territory or habitat, aids in diagnosing, treating, and predicting a patient's condition as well as determining their Prakriti, or body constitution. The criteria used for evaluating Bhumi Desha (geographical land) in the classics were too general and are not used in modern practice. Due to the diverse ecosystem of the Belagavi district, the regions must be accurately identified and mapped into distinct geographical areas. Methods: The best Bhumi Desha (geographical land) was determined by a cross-sectional study, which included Sadharana Desha (mixed land), Anupa Desha (wet fields), and Jangala Desha (dry lands). The Google Earth tool was then used to map these geo-geographical places into different Bhumi Desha based on the parameters that were collected. To assess the pradhana prakriti, around 4767 participants were selected by a random sampling method (lottery method) from 15 distinct geo-geographic regions of the Belagavi district. Results: There were 10.91% wet land, 21.86% mixed land, and 67.22% dry land was found. Discussion: It was found that there is a significant association between ‘Desha’ (geographical land) and ‘Prakriti’ (body constitution) (P-value < 0.001) at a 5% level of significance. Vata pradhana prakriti people were more prevalent in dry areas, Kapha pradhana prakriti people were more prevalent in wet/damp areas, and Samadhatuja prakriti people were more prevalent in Sadharana Desha. Conclusion: The goal of this study was to examine the person's Primary prakriti and Desha characteristics. The Bhumi desha-wise map that was created showed each of the three categories of Dehsa. The results of the current study showed a significant relationship between Desha and Prakriti, with a P-value of less than 0.001.

Dosha characteristics interpreted in ulnar nerve conduction metrics and its association acoss deha prakriti types (body constitutions)-a cross sectional study

2025-05-13T13:24:26+00:00

Introduction: Prakriti (somatic constitution) is a novel ayurvedic concept that stresses each person's individualized treatment. The clinical significance of these gunas (attributes) can be correlated with the range of nerve conduction. Nerve conduction studies assist in the evaluation of predisposition to neuromuscular diseases by providing a physiologic assessment of the peripheral nerves. This study aims to correlate the dosha characters with neuromuscular conduction study parameters and further study its association with deha prakriti types. Methodology: This was a cross-sectional study where the healthy volunteers of the age group between 18 years and 60 years were included, and the subjects with a history of neuromuscular disorders, psychiatric medicines, diabetes, and any other illnesses that may affect the neurological functions were excluded. The prakriti evaluation was done using a standardized CCRAS prakriti web portal followed by nerve conduction tests with a calibrated OCTOPUS-4 channel electromyography (EMG) machine. The study parameters were prakriti (questionnaire), latency of nerve (milliseconds), nerve amplitude (millivolts), and nerve conduction velocity (NCV) (meters per second) on 213 healthy volunteers divided into 10 groups of prakriti. Data was analyzed using one-way ANOVA followed at p<0.05. Results: The ulnar MNCV of the vata pradhana prakriti was higher (78.8 ± 14 m/s), followed by the kapha pradhana prakriti (86.91 ± 7 m/s); the vatakapha pradhana prakriti had the third highest MNCV, followed by the kapha vata pradhana prakriti. One-way ANOVA showed a statistically significant difference between types of deha prakriti with consideration of motor latency 1 and motor latency 2 at the wrist, (F(8,204) = 514, p = 0.001) and (F(8,204) = 2.307, p = 0.022), respectively. Conclusion: This study has observed a difference in ulnar motor nerve conduction parameters across deha prakritis, establishing objective parameters for kapha dosha-sandra (thickness) and snigdha (lubricated) nerve fibers exhibiting faster motor nerve conduction.

Efficacy of Ashwagandhadi Leha Granules in comparison to Hyderabad mix on Karshya, undernutrition IAP grade I and II in children – a double blind randomized controlled clinical trial

2025-06-12T11:26:24+00:00

INTRODUCTION: Apatarpanajanya vyadhi with krushata (wasting) as a cardinal feature is a Karshya and is correlated with undernutrition. Underweight prevalence has decreased from 35.8% to 32.1% (NFHS 5 report). Despite various programmes like Akshaya patra, Rashtriya Bala Swasthya Karyakram to curb under nutrition, the results not satisfactory. Thus, WHO and GOI prioritize malnutrition research with emphasis on traditional food recipes. Researches on formulations like Drakshadi Gritha, Ashwagandha Granules and Prinan Modaka, Balya Biscuit and Kooshmanda avaleha mostly exploratory with few being controlled clinical trials. Studies using z scores assessment on WHO growth charts. Ashwagandhadi leha mentioned in Sahasrayogam – Lehya Prakarana indicated in Karshya possesses Balya property. Difficulty with administration of ghrita, leha yoga were due to the texture, smell or taste of. Thus, a pharmaceutically modified Ashwagandhadi leha granules was proposed for research. This is expected to be wholesome combination by virtue of its ingredients that cover the calorie, proteins, fat and calcium needs of the child along with pepper to enhance bio availability and immunity. Thus, the present study intends to evaluate the effect of Ashwagandhadi leha granules on Karshya, undernutrition IAP grade I and II. MATERIALS AND METHODS: This is a prospective, close-label, double blind randomized controlled clinical trial of total 40 participants diagnosed with Karshya, Undernutrition IAP grade I and II. Trial group subjects will receive for age group 2 to 4 years it will be 15g and for age group 5 to 6 years it will be 20g of Ashwagandhadi leha granules with 100ml milk BD orally, after food for 90 days. Control Group subjects will receive Hyderabad Mix in the similar way. DISCUSSION: The study is expected to show that the intervention of Ashwagandhadi leha granules is as effective as Hyderabad Mix in managing Karshya, Undernutrition IAP grade I and II.

Effect of Dhanyamla Parisheka by conventional method and classical method in the management of Sandhigatavata – A randomized comparative clinical trial

2025-05-09T13:36:51+00:00

Background: Osteoarthritis (OA) is one of the most common and disabling musculoskeletal disorders, which is extremely common in the elderly population, affecting approximately 22% to 39% of the Indian population. In this regard, the treatment of OA of the knee requires both pharmacological and non-pharmacological approaches, which have its drawbacks as they are often costly, painful, and associated with potential side effects. Whereas Ayurveda offers a holistic and relatively painless treatment, one such therapy is Dhanyamla Parisheka, it is indicated in the management of ailments due to Vata-kapha vitiation. Objectives and Trial Design: The present study is a randomized, open-label parallel-group clinical trial. The objective was to study the effect of Dhanyamla parisheka in the management of sandhigata vata and determine the difference in the effect of dhanyamala parisheka when used by two different parisheka methods, the classical (as per classical text) and the convenient conventional method. A total 42 participants diagnosed with sandhigata vata were enrolled and randomly allocated into two groups: Group A (Classical method/Standard control) and Group B (Conventional method/trial), with 21 patients in each group. Methods: Group A underwent Parisheka using the Classical method described in Ayurvedic texts, while Group B received treatment using a simplified version for ease of clinical application for 7 days. Results: Most of the clinical parameters, except Sandhisputana (crepitus), showed statistically significant results noted in both groups, possibly due to the analgesic and anti-inflammatory treatment and absence of Rasayana or tissue-regenerating interventions. Conclusion: There was no significant difference observed in the effectiveness of the two methodologies; the conventional method demonstrated comparable efficacy. However, Dhanyamla Parisheka proved effective in the management of Sandhigata Vata.

Role of structured yoga protocol on subjective wellbeing of females suffering from premenstrual syndrome- An open-labelled single-arm clinical study

2025-06-13T08:34:14+00:00

Background: “Premenstrual Syndrome” (PMS) is a psychosomatic condition of unknown cause; approximately 80-90% of people experience PMS symptoms. It is reducing the life satisfaction and mental peace of women. The primary treatment line in modern science is sedatives, SSRIs, anxiolytics, but they cause so many side effects. Therefore, we planned this research to investigate the potential benefits of yoga in alleviating PMS symptoms.

Methods: We developed a 30-minute yoga protocol as part of a non-randomized single-group open-label clinical trial, with a sample size of 50. The intervention began after the second menstrual cycle, which followed the diagnosis of the condition based on observations from two menstrual cycles. 47 patients completed the trial, while 3 dropped out. The WHO QOL Scale was used for assessment.

Results: Statistical data has shown a significant improvement in subjective well-being of females suffering from PMS

Conclusion: Yoga protocol is an effective, natural, non-pharmacological treatment for premenstrual syndrome, and it is very helpful in increasing the subjective well-being and mental peace of women.

Safety practice of rasaoushadhis in Amavata Bridging with renal parameters- A case series

2025-06-12T03:10:21+00:00

Background: Amavata is a disorder in which the Vata Dosha is vitiated and Ama accumulates in the joints, simulating what is now known as rheumatoid arthritis (RA). A total of 10 patients who had classical lakshanas of Amavata, i.e., Sadana, alasaka, gourava, arochaka, and vedana with elevated ESR and RA titer positive, were taken, and shamanaoushadhis having rasaoushadhis were used to assess the safety of visceral organs by using herbomineral medication consumed for longer duration. Clinical findings: A total of 10 patients having classical lakshanas of Amavata were diagnosed, and ama lakshanas like aruchi, govrava, and alasya were assessed. Along with that blood test, ESR, serum creatinine, and blood urea were done on every 30^th day of follow-up. Results: Shamanaoushadhis were taken for the period of 120 days in total with evaluation of ESR, serum creatinine, and blood urea after every 30 days of the intervention. Despite consuming the herbomineral combinations for 120 days, patients did not show any adverse effects on renal parameters, indicating the safety of these combinations in combating chronic illnesses like Amavata. Conclusion: Patients suffering from Amavata, who had elevated ESR levels, consumed Shamanoushadhis for a total of 120 days, specifically Amavatari rasa, Mritunjaya rasa, Shudha vatsanabha churna, and Rasnasaptaka Kashaya with lukewarm water. They experienced relief in symptoms and maintained their cellular renal functions. This case series shows the importance of the use of rasaoushadhis for blood investigations in chronic cases and for longer durations.