ROLE OF DOOSHIVISHARI AGADA ON TERATOGENIC EFFECT OF CYFLUTHRIN IN EXPERIMENTAL MODEL W.S.R. FETAL WEIGHT AND HEIGHT

Abstract

Background: Pesticides are known for their toxicity on the mammalian system including embryonic development. Cyfluthrin (Trade name: Baygon and Solfac) is used commonly in India and reported to be a teratogenic agent and reported for low birth weight and stunned fetuses (short height), and dooshivishari agada (DVA) commonly use in conditions like garavishajanya dooshivisha. Aims: To evaluate the efficacy of dooshivishari Agada in cyfluthrin induced Teratogenicity with respect to body weight and height. Materials & Methods: The 30 pregnant swiss albino mice were divided in to 3 groups of 10 each and 1^st group was control administered with normal saline, 2^nd group given cyfluthrin 32mg/kg body wt, 3^rd group cyfluthrin(32mg/kg body wt) With DVA 1.2gm/kg body wt orally during the organogenesis period i.e. from 5^th to 14^th day. Statistical analysis used: It was analyzed using student t test using software graph pad prism version 6. Results: There weights in 1st and 3rd groups are nearly equal and showed the increase of weight and height in3rd group i.e. treated group, weight: Group1-1.24±0.15, Group2-0.68±0.13, and group 3-1±0.11. Height: Group1-2.03±0.23, Group2-1.22±0.28, Group3-1.78±0.21 (Mean± SEM). Comparing the group 2 with group 3 the p value<0.05 in both the criteria’s. Conclusion: The dooshivishari agada has shown the significant effect in increasing the weight and height of the fetuses which were exposed to the teratogenic agent