Ayurvedic management of Nicolau Syndrome W.S.R to Agantuja Vidhradhi and Kotha – A case report

Authors

  • Y M Santosh Reader, Department of shalyatantra, KAHER’S Shri B M Kankanawadi Ayurveda Mahavidhyalaya
  • Ujjwal Gupta 3rd Year PG Scholar, KAHER’S Shri B M Kankanawadi Ayurveda Mahavidhyalaya Shahapur, Belagavi, Karnataka
  • Tarun Pawar 2nd Year PG Scholar, KAHER’S Shri B M Kankanawadi Ayurveda Mahavidhyalaya Shahapur, Belagavi, Karnataka

DOI:

https://doi.org/10.70066/jahm.v13i6.1824

Keywords:

Agantuja Vidhradhi, Bhedana Karma, Chedana Karma, Kotha, Nicolau syndrome, Case report

Abstract

Introduction: Injection therapy is a part of general clinical practice in today’s life by doctors. Sometimes, unanticipated outcomes of injection therapy are seen in the clinical practice Nicolau syndrome (NS) is one such rare cutaneous adverse reaction found at the site of injection.  Freudenthal and Nicolau first explained it as a side effect of the bismuth salts used to treat syphilis in 1924 and 1925, respectively.

Patient information: A 38-year-old male presented with complaints of mild fever and discolouration of skin over left gluteal region later turned into necrosis of skin.

Therapeutic intervention: The case was diagnosed as Nicolau syndrome according to modern science and Agantuja vidhradhi as per Ayurveda progressing to Kotha. The case was treated successfully with Bhedana Karma and Chedan Karma followed by Vrana Shodhana, Ropana Chikitsa, and oral medications.

Results: The wound was completely healed with mild contracture in 42 days.

Conclusions: NS can be managed successfully with Ayurveda treatment but there is a need to exercise utmost care during the administration of any injection therapy and awareness about this condition

Author Biographies

Ujjwal Gupta, 3rd Year PG Scholar, KAHER’S Shri B M Kankanawadi Ayurveda Mahavidhyalaya Shahapur, Belagavi, Karnataka

3rd Year PG Scholar, Department of Shalyatantra.

KAHER’S Shri B M Kankanawadi Ayurveda Mahavidhyalaya Shahapur, Belagavi, Karnataka

Tarun Pawar, 2nd Year PG Scholar, KAHER’S Shri B M Kankanawadi Ayurveda Mahavidhyalaya Shahapur, Belagavi, Karnataka

2nd Year PG Scholar, Department of Shalyatantra

KAHER’S Shri B M Kankanawadi Ayurveda Mahavidhyalaya Shahapur, Belagavi, Karnataka

References

Kim KK. Nicolau syndrome: A literature review. World Journal of Dermatologyy. 2015;4(2):103.

Kim KK. Nicolau Syndrome in Patient Following Diclofenac Administration: A Case Report. Annals of Dermatology. 2011 Jan 1;23(4):501–1.

Luton K, Garcı́aC, Eduardo David Poletti, Koester G. Nicolau Syndrome: three cases and review. International Journal of Dermatology. 2006 Feb 23;45(11):1326–8.

MARANGI GF, Pierluigi GIGLIOFIORITO, TOTO V, LANGELLA M, Tiziano PALLARA, PERSICHETTI P. Three cases of embolia cutis medicamentosa (Nicolau’s syndrome). The Journal of Dermatology. 2010 Apr 29;37(5):488–92.

Shastri, K.A.D. (2017) ‘Nidana Sthana Chapter- 09, Vidhradhinidana’, in Susruta Samhita of Maharsi- Susruta Edited with Ayurveda- Tattva- Sandipika. 2017th edn. Varanasi, India: Chaukhamba Sanskrit Sansthan (1), p. 342–342.

Shastri, K.A.D. (2017) ‘Chikitsa Sthana Chapter- 16, Vidhradhichikitsa’, in Susruta Samhita of Maharsi- Susruta Edited with Ayurveda- Tattva- Sandipika. 2017th edn. Varanasi, India: Chaukhamba Sanskrit Sansthan (1), p. 342–342.

De Sousa R, Dang A, Rataboli P. Nicolau syndrome following intramuscular benzathine penicillin. Journal of Postgraduate Medicine. 2008;54(4):332-4.

George AA, Sharma V, Shailaja SV. CRITICAL ANALYSIS OF VRANAPAHARIRASA IN VRANA. World Journal of Pharmaceutical and life sciences. 2005 Apr 8;2021(9).

Rawat N, Yadav Y, Mitra S, Sharma U, Sharma KC. ANTI-INFLAMMATORY AND ANTI-MICROBIAL ACTION OF TRIPHALA GUGGULU: A REVIEW. Int J Res Ayurveda Pharm. 2022 Aug 30;13(04):121-30.

Shetty P, Kedukodi P, Kamath S et.al. Gandhaka rasayana: possible role as a modulator of fibroblast cell function in wound healing. Int J Health Sci Res. 2020; 10(6):36-45.

Pal S, Ramamurthy A, Mahajon B. Arogyavardhini Vati: A theoritical analysis. J Sci Innov Res. 2016 Dec 25;5(6):225-7.

Wen M, Chen Q, Chen W, Yang J, Zhou X, Zhang C, et al. A comprehensive review of Rubia cordifolia L.: Traditional uses, phytochemistry, pharmacological activities, and clinical applications. Front Pharmacol. 2022 Sep 9;13:1-24

Upadhyay A, Kumar K, Kumar A, Mishra H. Tinospora cordifolia (Willd.) Hook. f. and Thoms. (Guduchi) - validation of the Ayurvedic pharmacology through experimental and clinical studies. Int J Ayurveda Res. 2010;1(2):112

Gupta V, Keshari BB, Tiwari SK, Murthy KHHVSSN. A review on Antidiabetic action of Asanadi Gana. Int J Res Ayurveda Pharm. 2013 Oct 27;4(5):638-46.

Shindhe P, Killedar R, D L, M S, Madiwalar M. Evaluation of Wound healing activity of Jatyadi Ointment and Jatyadi taila in the management of Shuddha Vrana - A Randomised Controlled Trial. Annals of Ayurvedic Medicine. 2020;9(2):98.

Bhat K, Vishwesh B, Sahu M, Shukla V. A clinical study on the efficacy of Panchavalkala cream in Vrana Shodhana w.s.r to its action on microbial load and wound infection. AYU. 2014;35(2):135.

Additional Files

Published

2025-07-17

How to Cite

Santosh , Y. M., Gupta, U., & Pawar, T. (2025). Ayurvedic management of Nicolau Syndrome W.S.R to Agantuja Vidhradhi and Kotha – A case report. Journal of Ayurveda and Holistic Medicine (JAHM), 13(6), 155-161. https://doi.org/10.70066/jahm.v13i6.1824