A Pharmaceutico-analytical investigation of Rajat Bhasma synthesized through modified techniques employing mercurial compounds
DOI:
https://doi.org/10.70066/jahm.v13i5.1916Keywords:
Rajat Bhasma, Rajat Marana, Silver BhasmaAbstract
Background: The quality of metal Bhasma and the number of Puta (specific quantum of heat) required for its preparation depends on the raw materials used. Mercury and its compounds are considered superior for producing metallic Bhasma, which can be applied in the form of an amalgam with metal or as a paste over metal foil. Aim: To evaluate the impact of equal quantities of mercury and sulfur in paste form on Bhasma preparation and to compare the results with those of previous studies. Methodology: Rajat Bhasma (RB) was prepared using equal quantity of Shuddha Parad (processed mercury) with Shuddha Gandhak (processed sulphur) in every Puta and in the paste form in the first Puta. Rajat Bhasma was analysed for ancient Bhasma Praiksha (tests), its physicochemical parameters, elemental analysis through XRF, crystal study through XRD, and particle size through dynamic light scattering (DLS). Results: Three Puta were required to prepare an RB that passed all ancient parameters. RB contained 17.7 % silver, 30.7 % mercury, and 50.8 % sulfur. The XRD study showed peaks of silver sulfide in the RB. RB contains particles in the range–300-400 nanometres. Conclusion: Adopting the use of Kajjali in the first Puta and an equal quantity of mercury and sulphur in the remaining Puta’s reduces the number of Puta’s required to three. This also resulted in and percentage of silver, mercury, and sulfur in the final RB.
References
References:
Bhargav SC, Reddy KR. Pharmaceutical study of Kant Lauha Bhasma. International Journal of Ayurvedic Medicine 2011; 2(4):199-213.
Rajendran N, Pemiah B, Rajan KS, Krishnan UM, Sethuraman S, Krishnaswamy S. Role of gallic acid in the preparation of an iron based Indian traditional medicine Lauha bhasma. Int J Pharm Pharm Sci 2012;4:45-8.
Nagarajan S, Pemiah B, Krishnan UM, Rajan KS, Krishnaswamy S, Sethuraman S. Physico- chemical characterization of lead based Indian traditional medicine - Naga bhasma. Int J Pharm Pharm Sci 2012;4:69-74.
Kulkarni DA (editor). Commentary: Vigyan Bodhini on Rasa Ratna Samucchaya of Vagbhata, Part I, Chapter 5, Verse 14, New Delhi; Mehardas Lachmandas Publication; Reprint edition; 1998; 94.
Shastri KN, Shastri D (editors). Commentary: Rasa Vigyan on Rasa Tarangini of Sadanand Sharma, Chapter 16, Verse 46-51, 11th edition, New Delhi; Motilal Banarasidas; 2021;394.
Durga BM, Raju M, Sridurga, Venkata SK. Analytical Standardization of Rajata Bhasma. International Journal of Research in AYUSH and Pharmaceutical Sciences 2018;2(3):229-238.
Naik G, Medikeri S, Doddamani MS. Physicochemical Characterization of Rajata Bhasma. International Ayurvedic Medical Journal {online} 2018;6(8):1637-44. Available from: http://www.iamj.in/posts/images/upload/1637_1644.pd
Gokarn R, Patgiri B, Hiremath SG. Pharmaceutical Standardization of Rajat Bhasma. Annals of Ayurvedic Medicine 2013;2(1-2):7-15.
Mishra B, Vaishya R (Editors). Bhavaprakasha Nighantu of Bhavaprakasha, Volume I, Takra Varga Adhyaya, Verse 2-8, 11th Edition, Varanasi; Chaukhamba Sanskrit Bhawan; 2010;771.
Vaishya S. Rasayanasara, Volume I, Paribhasha Prakaran, Verse no.55-60,7th special edition, Varanasi; Chaukhambha Krushnadas Academy; 2005; 59.
Kulkarni DA (editor). Commentary: Vigyan Bodhini on Rasa Ratna Samucchaya of Vagbhata, Part I, Chapter 5, Verse 13, Reprint edition, New Delhi; Mehardas Lachmandas Publication; 1998; 93.
Shastri KN, Shastri D (editors). Commentary: Rasa Vigyan on Rasa Tarangini of Sadanand Sharma, Chapter 16, Verse 22-26, 11th edition, New Delhi; Motilal Banarasidas; 2021;387.
Kulkarni DA (editor). Commentary Vigyan Bodhini on Rasa Ratna Samucchaya of Vagbhata, Part I, Chapter 3, Verse 20-22, reprint edition, New Delhi; Mehardas Lachmandas Publication; 1998;45.
Mishra GS (editor). Commentary: Arthavidyotini and Arthraprakshini on Ayurveda Prakash of Madhav, Chapter.1, Verse 165, 4th edition, Varanasi; Chaukhambha Bharati Academy;1994;92.
Shastri KN, Shastri D (editors). Commentary: Rasa Vigyan on Rasa Tarangini of Sadanand Sharma, Chapter 16, Verse 22-25,11th edition, New Delhi; Motilal Banarasidas; 2021;390.
Siddhinandan Mishra (editor). Rasendra Chudamani of Somadeva, Chapter 4, Verse 31,Varanasi; Chaukhamba orientalia; 2004; 42.
Siddhinandan Mishra (editor). Rasendra Chudamani of Somadeva, Chapter 4, Verse 30, Varanasi; Chaukhamba orientalia; 2004;42.
Siddhinandan Mishra. Bhaishajya Kalpana Vijnan. Varanasi; Chaukhamba surabharati prakashana; 2011;78.
Siddhinandan Mishra. Bhaishajyakalpana Vijnan. Varanasi; Chaukhamba surabharati prakashana; 2011;78.
Siddhinandan Mishra (editor). Rasendra Chudamani of Somadeva, Chapter 4, Verse 32, Varanasi; Chaukhamba orientalia; 2004; 42.
Siddhinandan Mishra (editor). Rasendra Chudamani of Somadeva, Chapter 4, Verse 33, Varanasi; Chaukhamba orientalia; 2004;42.
Anonymous. Ayurvedic Pharmacopoeia of India, Part II, Volume I, Appendix 3.3, 1st edition, New Delhi; Government of India, Ministry of Health and Family Welfare, Department of Ayurveda, Yoga and Naturopathy, Unani, Siddha and Homoeopathy, The Controller of Publications; 2007;191.
Anonymous. Ayurvedic Pharmacopoeia of India, Part II, Volume I, Appendix 2.2.3, 1st edition, New Delhi; Government of India, Ministry of Health and Family Welfare, Department of Ayurveda, Yoga and Naturopathy, Unani, Siddha and Homoeopathy, The Controller of Publications; 2007;140.
Anonymous. Ayurvedic Pharmacopoeia of India, Part II, Volume I, Appendix 2.2.4, 1st edition, New Delhi; Government of India, Ministry of Health and Family Welfare, Department of Ayurveda, Yoga and Naturopathy, Unani, Siddha and Homoeopathy, The Controller of Publications; 2007;140.
Anonymous. Ayurvedic Pharmacopoeia of India, Part II, Volume I, Appendix 2.2.5, 1st edition, New Delhi; Government of India, Ministry of Health and Family Welfare, Department of Ayurveda, Yoga and Naturopathy, Unani, Siddha and Homoeopathy, The Controller of Publications; 2007. p. 140.
Anonymous. Ayurvedic Pharmacopoeia of India, Part II, Volume I, Appendix 2.2.10, 1st edition, New Delhi; Government of India, Ministry of Health and Family Welfare, Department of Ayurveda, Yoga and Naturopathy, Unani, Siddha and Homoeopathy, The Controller of Publications; 2007;141.
Thakur RS, Gupta LN, Neeraj Kumar B. Standard manufacturing procedure of Teekshna lauha bhasma. Journal of Ayurveda and Integrative Medicine.2016;7:100-108. http://dx.doi.org/10.1016/j.jaim.2015.08.003.
Wadekar MP, Rode CV, Bendale YN, Patil KR, Prabhune AA. Preparation and characterization of a copper based Indian traditional drug: Tamra Bhasma. J Pharm Biomed 2005;39:951-5.
Sharma D, Sharma A, Preeti. Pharmaceutical Study of Rajata Bhasma by Two Different Methods. World Journal of Pharmaceutical and Medical Research 2022;8(2):178 – 91.
Ag2S (Silver Sulfide) Molar Mass. Available from https://www.chemicalaid.com/tools /molarmass.php?formula=Ag2S&hl=en#google_vignette [Last accessed on 2024 Aug 16].
Pritika. Analytical Study of Rajata Bhasma w.s.r. to Ayurvedic and Modern Parameters. Int J Ayu Pharm Chem 2019;11(3):402-411.
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