Pharmaceutical Analysis and Gas Chromatography-Mass Spectrometry (Gc-Ms) Profiling of Phytoconstituents in Jatamansyadi Taila for Potential Use in Neurobehavioral and Neurodevelopmental Conditions
DOI:
https://doi.org/10.70066/jahm.v13i10.2082Keywords:
Keywords: Jatamansyadi taila, Pharmaceutico-analytical study, GCMS, Phytoconstituents, Unmada, Neurobehavioral disorders.Abstract
Background: Jatamansyadi Taila is a unique Ayurveda formulation mentioned in Sushruta Samhita derived from Aparajithayoga, mentioned in Amanushopasarga Pratisedha Adhyaya of Uttarasthana. It is indicated in the management of Manasa rogas like Unmada (neurobehavioral disorders), Apasmara(epilepsy) and Graha doshadi sarva vikaras (psychosis & psychosomatic disorders) with a principal focus of this study being on Unmada roga (neurobehavioral disorders). This relatively unexplored formulation is prepared based on the principle of Yukti by selecting specific drugs from the Yoga. Aim: To understand the potential therapeutic efficacy of identified phytoconstituents and its underlying mechanisms in managing neurobehavioral conditions. Materials & Methods: Jatamansyadi Taila was tested for its safety and suitability for administering in patients using parameters such as physicochemical parameters, organoleptic characteristics and microbial limit test. Instrumental analysis using GC-MS was carried out to detect the presence of phytoconstituents in Jatamansyadi Taila. Results & Discussion: GC-MS analysis revealed 32 phytoconstituents, among which ten showed major peak areas reported as 1,6,10-Dodecatrien-3-ol, 3,7,11-trimetl , Asarone , 1,3a-Ethano(1H)inden-4-ol, Octadecanoic acid, 3-[(1-oxohexadecyl, Hexadecanoic acid, 2-[(1-oxododecyl), 9-Octadecen-1-ol, (Z)- Myristic acid vinyl ester ,Stigmasta-3,5-diene, Glycerol 2-acetate 1,3-dipalmitate and (+)-Sesamin. Among these, several constituents possess neuroprotective actions supporting Ayurveda’s approach in managing neurobehavioral disorders. Conclusion: The present study provides preliminary analytical data of Jatamansyadi Taila on organoleptic, physicochemical and microbial parameters. As this formulation is not mentioned either in the Ayurvedic Pharmacopoeia of India (API) or in the Ayurvedic Formulary of India (AFI), thus the outcomes of Jatamansyadi Taila serve as preliminary analytical benchmarks for future standardization. Furthermore, this study helps in contributing to the validation of classical Ayurveda’s approach in managing various neurobehavioral conditions.
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