Langhanam in Ayurveda; its molecular and metabolic impact on Adipogenesis – A review.
DOI:
https://doi.org/10.70066/jahm.v13i8.2164Keywords:
Keywords: adipogenesis, PPARγ, santharpana, santharpana janya vyadhi, anti-adipogenicity, langhanam.Abstract
Introduction: Adipogenesis is a process in which the immature pluripotent mesenchymal stem cells are converted into pre-adipocytes and differentiates into mature adipocytes in adipose tissue. Process of adipogenesis and associated illness shows close resembles to santharpana (nourishing therapy) and santharpana janya vyadhis (diseases due to excess nourishment) mentioned in Charaka Samhita, and has advocated various types of langhana as the treatment. This is a review that shows the relation between the action of langhana karma with the advance research methods that causes anti-adipocytic activity. Materials and methods: References of santharpana, langhana and its types from Charaka Samhita, Ashtanga Hridaya and Sushruta Samhita. Different published articles on adipogenesis and anti – adipogenicity with key words, adipogenesis, anti – adipogenicity, PPARγ agonist PPARγ and fasting, PPARγ and exercise, PPARγ and sun exposure were used. Period: from 2013 to 2023. Result: While reviewing it is found that types of langhana such as upavasa (fasting), vyayama (exercise) and atapa seva (exposure to sun) have significant effects on adipogenesis by changing the expression levels of PPARY gene. Hence, comparison of various types of Ayurvedic langhana therapy with several experimental studies, reveals the potential of following basic principles of Ayurveda as well as langhana therapy. Conclusion: Of the 10 types of langhana karma the 3 types have experimentally proven benefits in modifying adipogenesis. The other types have been used by Ayurvedic physicians since generations for almost all diseases as the first line of treatment. Conventional line of treatments has vast side effects when compared with langhanam in treating the diseases related to adipose tissue. Hence utilizing the vast knowledge of langhanam in Ayurveda, could open a vast range of significant treatment modalities in addressing adipogenic as well as metabolic related diseases in the present era
References
Choe, Sung S. Adipose Tissue Remodelling: Its Role in Energy Metabolism and Metabolic Disorders. Frontiers in Endocrinology.2016 April; 7:178543. Available from: https://doi.org/10.3389/fendo.2016.00030
Mathur, Prashant, and Rakesh Pillai. Overnutrition: Current Scenario & Combat Strategies. The Indian Journal of Medical Research. 2019 Sep; 149(6) :695-705. Available from: https://doi.org/10.4103/ijmr.IJMR_1703_18
R. Vidyanath (editor). Illustrated Charaka Samhita English translation with Chakrapani commentary, vol. 1. Sutrasthana, chapter 22, verse no.18. 1st edition, Varanasi; Chaukhambha Prakashana; 2020;637
Ambele MA, Dhanraj P, Giles R, Pepper MS. Adipogenesis: A complex interplay of multiple molecular determinants and pathways. Int J Mol Sci. 2020 June;21(12):4283. Available from: https://doi.org/10.3390/ijms21124283
Vidal-Puig A, Jimenez-Liñan M, Lowell BB, Hamann A, Hu E, Spiegelman B, et al. Regulation of PPAR gamma gene expression by nutrition and obesity in rodents. J Clin Invest. 1996 June;97(11):2553–61.Available from: https://doi.org/10.1172/JCI118703
Sarjeant K, Stephens JM. Adipogenesis. Cold Spring Harb Perspect Biol. 2012 Sep 1;4(9): a008417. Available from: https://doi.org/10.1101/cshperspect.a008417
Nazari M, Minasian V, Sharifian M J. Effect of Exercise Training on Peroxisome Proliferator-Activated Receptor γ (PPAR-γ) Level: A Systematic Review. Asian J Sports Med. 2024 Dec;15(1):e136944. Available from: https://doi.org/10.5812/asjsm-136944.
Lee, Jongsung, et al. "Ultraviolet A Regulates Adipogenic Differentiation of Human Adipose Tissue-derived Mesenchymal Stem Cells via Up-regulation of Kruppel-like Factor 2." The Journal of Biological Chemistry2010 Oct;285(42): 32647 – 56; Available from: https://doi.org/10.1074/jbc.M110.135830.
Kim EJ, Kim YK, Park CH, Lee KH, Eun HC, Chung JH. UV-induced inhibition of adipokine production in subcutaneous fat aggravates dermal matrix degradation in human skin. Sci Rep. 2016 May; 6:25616; Available from: https://doi.org/10.1038/srep25616
Wang QA, Tao C, Gupta RK, Scherer PE. Peroxisome proliferator-activated receptor γ and its role in adipocyte homeostasis and thiazolidinedione-mediated insulin sensitization. Mol Cell Biol. 2018 Mar;38(10): e00677-17. Available from: https://doi.org/10.1128/MCB.00677-17
Cariou B, Charbonnel B, Staels B. Thiazolidinediones and PPARγ agonists: time for a reassessment. Trends Endocrinol Metab. 2012 May;23(5):205–15. Available from: https://doi.org/10.1016/j.tem.2012.03.001
Wright MB, Bortolini M, Tadayyon M, Bopst M. Minireview: Challenges and opportunities in development of PPAR agonists. Mol Endocrinol. 2014 Nov;28(11):1756–68. Available from: https://doi.org/10.1210/me.2013-1427
R. Vidyanath (editor). Illustrated Charaka Samhita English translation with Chakrapani commentary, vol. 1. Sutrasthana, chapter 23, verse no.3,4. 1st edition, Varanasi; Chaukhambha Prakashana; 2020;649
R. Vidyanath (editor). Illustrated Charaka Samhita English translation with Chakrapani commentary, vol. 1. Sutrasthana, chapter 22, verse no.8. 1st edition, Varanasi; Chaukhambha Prakashana; 2020;635
R. Vidyanath (editor). Illustrated Charaka Samhita English translation with Chakrapani commentary, vol. 1. Sutrasthana, chapter 23, verse no.5,6,7. 1st edition, Varanasi; Chaukhambha Prakashana; 2020;649
R. Vidyanath (editor). Illustrated Charaka Samhita English translation with Chakrapani commentary, vol. 1. Sutrasthana, chapter 22, verse no.24. 1st edition, Varanasi; Chaukhambha Prakashana; 2020;638
R. Vidyanath (editor). Illustrated Charaka Samhita English translation with Chakrapani commentary, vol. 1. Sutrasthana, chapter 22, verse no.19. 1st edition, Varanasi; Chaukhambha Prakashana; 2020;638
R. Vidyanath (editor). Illustrated Charaka Samhita English translation with Chakrapani commentary, vol. 1. Sutrasthana, chapter 22, verse no.20. 1st edition, Varanasi; Chaukhambha Prakashana; 2020;638
R. Vidyanath (editor). Illustrated Charaka Samhita English translation with Chakrapani commentary, vol. 1. Sutrasthana, chapter 22, verse no.22. 1st edition, Varanasi; Chaukhambha Prakashana; 2020;638
R. Vidyanath (editor). Illustrated Charaka Samhita English translation with Chakrapani commentary, vol. 1. Sutrasthana, chapter 22, verse no.23. 1st edition, Varanasi; Chaukhambha Prakashana; 2020;638
R. Vidyanath (editor). Illustrated Charaka Samhita English translation with Chakrapani commentary, vol. 1. Sutrasthana, chapter 22, verse no.12. 1st edition, Varanasi; Chaukhambha Prakashana; 2020;635
R. Vidyanath (editor). Illustrated Charaka Samhita English translation with Chakrapani commentary, vol. 1. Sutrasthana, chapter 22, verse no.34,35. 1st edition, Varanasi; Chaukhambha Prakashana; 2020;642
R. Vidyanath (editor). Illustrated Charaka Samhita English translation with Chakrapani commentary, vol. 1. Sutrasthana, chapter 22, verse no.36,37. 1st edition, Varanasi; Chaukhambha Prakashana; 2020;642
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