Preparation, Physicochemical Standardization with Gas Chromatography – Mass Spectrometry Analysis of Drakshadi Taila and its role in Nasal Disorders
DOI:
https://doi.org/10.70066/jahm.v14i1.2458Keywords:
Drakshadi Taila, Sneha Kalpana, Vataja Pratishyaya, GC-MS, Allergic rhinitisAbstract
Background: Nasya karma (Nasal instillation of medicine) is the procedure mentioned in Ayurveda where the medicine is given through nose. Preparation of Drakshadi Taila as explained in Vaidya Chintamani in the management of Nasagata Rogas (Nasal disorders), so the objective is to prepare and finding out the physico-chemical, organoleptic properties of the oil. Aim: To study the preparation, assuring the safety and identification of phytoconstituents and its potential mode of action in the management of Nasal disorders. Objectives : To understand the preparation of Drakshadi taila with ingredients Draksha, Shunthi, Vidanga, Pippali, Kushta, and Tila Taila, by classical method of taila Kalpana. To determine the analytical tests like physico - chemical parameters, and tests for heavy metals to assure the safety, purity of drug. Gas chromatography-mass spectrometry analysis to investigate potential properties of Drakshadi taila. Material and methods - For this study Ayurveda Samhitas authentic publications, the internet and modern medical literature, Instrumental analysis GC-MS carried out with instrument Shimadzu. Result and Discussion – The formulation complied with API standards like specific gravity less than 0.969, saponification value (190.26) less than 195, and peroxide value 1.41 Meq/kg, tests for heavy metals like lead, mercury, cadmium, and arsenic and it is under permissible limits, microbiological testing shows no detectable pathogenic contamination, all these fulfils WHO/API safety standards. GC-MS reveals 25 phytoconstituent molecules like Tetratetracontane, Glycidyl palmitoleate, etc aligning with the medicinal properties like anti- inflammatory, anti-asthamatic etc. Conclusion – As this drug is not mentioned in Ayurvedic Pharmacopoeia of India (API) and this is to establish the applicability of Drakshadi Taila Nasya in nasal disorders through quality control parameters mentioned in API includes physicochemical, microbial parameters and tests for heavy metals etc. to ensure its identity, purity and safety. Hence this study helps in validating the formulation in nasal disorders.
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