RANDOMIZED CONTROLLED, OPEN LABELED STUDY OF A HERBAL PREPARATION, LEKHANEEYA MAHAKASHAYA GHANAVATI IN DYSLIPIDEMIA PATIENTS

Abstract

Background: Research over the past 4 decades has consistently shown the burden of dyslipidemia to be very high in terms of morbidity, mortality and medical costs. Dyslipidemia, being a chronic disorder, needs to be managed with safe and effective medicines. The current study compares the efficacy of two herbal preparations, Lekhaneeya Mahakashaya Ghanavati and Shuddha Guggulu Vati in the management of dyslipidemia. Objective: To evaluate and compare the efficacy of Lekhaneeya Mahakashaya Ghanavati versus Shuddha Guggulu Vati in the management of dyslipidemia. Materials and Methods: In this randomized, interventional, active controlled, open-labeled study, a total of 29 dyslipidemic patients were randomly assigned to receive either Lekhaneeya Mahakashaya Ghanavati (LMG; n = 15)or Shuddha Guggulu Vati (SGV; n = 14) for a duration of 4 weeks. The findings with respect to assessment criteria were recorded at baseline and at end of 4 weeks and assessed for the efficacy of the interventions. Results: LMG elicited significant results in Total cholesterol, LDL cholesterol, HDLcholesterol. SGV elicited significant results in Triglycerides. Both the drugs elicited significant results in anthropometric measurements like weight, BMI, various body circumferences and skinfold thickness. However, there was no statistically significant difference between the effects elicited by LMG and SGV on all the parameters.Conclusion: The trial drug, Lekhaneeya Mahakashaya Ghanavati is effective in par with Shuddha Guggulu Vati in the management of dyslipidemia. Further randomized and large multicentric studies are recommended.