COMPARATIVE ASSESSMENT OF ANTIDEPRESSANT ACTION OF BRAHMI GHRITA PREPARED WITH FRESH AND TEN YEARS OLD COW GHEE ON CUMS ANIMAL MODEL

Authors

  • BHAVANA MENKUDLE

DOI:

https://doi.org/10.70066/jahm.v7i3.406

Keywords:

Brahmi[ SAT-F.449], PuranGhrita, BrahmiGhrita, antidepressant activity, CUMS

Abstract

Background: In traditional ayurved science, BrahmiGhrita [BG] is prescribed in the management of Unmada [depressive disorder]. It comprises of Brahmi, Ela and Puranghrita (10 years old clarified butter). However, generally Fresh Goghrita [Cow ghee] is utilized to prepare medicated ghee formulations. Till date antidepressant activity of BG in stress induced depression is not yet documented. Aims: Thus present study was conducted to assess antidepressant activity of two samples of BrahmiGhritaviz BG I and BG II in Chronic Unpredictable Mild Stress (CUMS) animal model.
Methods and material: Puran Ghrita, fresh Goghrita, BG I and BG II were administered orally at therapeutic dose [3.6gm/kg] along with application of specified stressors for 28 days. Animals were tested before and after treatment with Sucrose Preference and Force Swim test [FST]. Statistical test applied: ANOVA followed by Tuke’s test. Results: CUMS exposed animals showed depressive like behavior, with significant decrease in sucrose consumption and number of rotations in FST. Animals from standard drug [Imiprimine], BG I and BG II have shown significant increase in rotations in FST [p≤0.0001] as compared to CUMS group. BG I and BG II demonstrated significant behavioral changes in animals as compared to Puranghrita and fresh Goghrita respectively [p≤0.05]. Despite that, the role of Puran Ghrita in preparation of Brahmi Ghrita couldn’t be evaluated as against Brahmi Ghrita of fresh Goghrita in CUMS induced depressive rats.
Conclusions: BrahmiGhrita prepared from ten years old and fresh cow ghee have confirmed antidepressant like effect in CUMS study.

Author Biography

BHAVANA MENKUDLE

PG scholar, Dept. of Rasashastra and Bhaishajyakalpana, Bharati Vidyappeth [deemed to be university] college of Ayurved, Pune (INDIA)

Published

2021-04-23

How to Cite

MENKUDLE, B. . (2021). COMPARATIVE ASSESSMENT OF ANTIDEPRESSANT ACTION OF BRAHMI GHRITA PREPARED WITH FRESH AND TEN YEARS OLD COW GHEE ON CUMS ANIMAL MODEL. Journal of Ayurveda and Holistic Medicine (JAHM), 7(3). https://doi.org/10.70066/jahm.v7i3.406

Issue

Vol. 7 No. 3 (2019): Journal of Ayurveda and Holistic Medicine (JAHM)

Section

Original Research Article- Experimental Research

License

Copyright (c) 2021 BHAVANA MENKUDLE

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