Ayurvedic Approach to Atherogenic Dyslipidemia: A Prospective Interventional Case Series
DOI:
https://doi.org/10.70066/jahm.v14i6.2603Keywords:
ASCVD risk score, Atherogenic dyslipidemia, Case series, Medodushti, QRISK3 score.Abstract
Background: Atherogenic Dyslipidemia (AD) is recognized by elevated serum triglyceride (TG) and low-density lipoprotein (LDL) levels, along with reduced high-density lipoprotein (HDL) levels. Extensive research has shown that the raised levels of LDL and apolipoprotein B (Apo-B) are the main causative factors in the occurrence of atherosclerotic cardiovascular diseases. According to Ayurvedic perspective, the condition of AD can occur due to an imbalance in Jatharagni and Medodhatwagni, leading to Medodushti. Aim: This prospective interventional case series aims to evaluate the effect of an Ayurvedic treatment protocol, in regulating atherogenic dyslipidemia. Material and Methods: Total six patients with atherogenic dyslipidemia were selected in this case series. The treatment protocol included Udvartana (therapeutic powder massage) and Virechana (therapeutic purgation), along with oral Ayurvedic medications and dietary-lifestyle modification, administered for sixty days. The primary outcome was change in lipid levels and Apo-B, while secondary outcome comprised change in symptoms, body mass index (BMI), Atherosclerotic Cardiovascular Disease (ASCVD) risk score and QRISK3 score. The assessments were performed prior and post-treatment. Results: There was a reduction in symptoms and lipid levels, such as mean Sr.TG decreased by 62.67 mg/dL (29.51%), LDL by 84.13 mg/dL (51.45%), LDL/HDL ratio by 2.86 mg/dL (60.98%), and Apo-B by 73.40 mg/dL (43.64%), while improvement in HDL by 8.43 mg/dL (24.22%). The mean BMI decreased by 1.43 kg/m2 (5.23%) in sixty days.. There was a noticeable reduction in 10-year cardiovascular risk scores (ASCVD and QRISK3) shifting from moderate or high risk to low-risk categories, highlighting a reduction in atherogenic risk. Conclusion: The Ayurvedic treatment protocol of Udvartana and Virechana procedures, integrated with oral medications and dietary-lifestyle modifications, showed improvements in the condition of Atherogenic dyslipidemia. The improvements were observed in clinical symptoms, lipid profile parameters, and next 10-year cardiovascular risk scores.
References
Sharma A, Mishra A, Soni M, Chaudhary V. A comparative clinical efficacy study of Triphala Kwath and Trikatu capsules in the management of Medoroga w.s.r. to dyslipidemia. Ayushdhara: An International Journal of Research in AYUSH and Allied Systems. 2020 Sept-Oct; 7(5):2864-74. Available from: https://doi.org/10.47070/ayushdhara.v7i5.624
Jhosmer BC, Fiorella EZ, Luisa Erika MV, Joan AL, Rafael TL, Carmen IG, et al. Global prevalence of dyslipidemias in the general adult population: a systematic review and meta-analysis. Journal of Health, Population and Nutrition. 2025 Aug; 44(308):1-11. https://doi.org/10.1186/s41043-025-01054-3
World Health Organisation. WHO fact sheet: Cardiovascular diseases (CVDs) [Internet]. Geneva: World Health Organization; 2025 July 31 [cited 2026 Apr 17]. Available from: https://www.who.int/news-room/fact-sheets/detail/cardiovascular-diseases-(cvds).
Rao SV, Donoghue M, Marc R, Rab T, Tamis-Holland J, et al. ACC/AHA/ACEP/NAEMSP/SCAI Guideline for the Management of Patients with Acute Coronary Syndromes: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. American Heart Association. 2025 April 01;151(13):e771-e862. Available from: https://doi.org/10.1161/CRI.0000000000001309
Jameson JL, Fauci AS, Kasper DL, Hauser SL, Longo DL, Loscalzo J, editors. Harrison’s Principles of Internal Medicine, 21st ed, New York: McGraw-Hill;2022; 2444-2458.
Tripathi B, (editor). Charak Samhita of Charaka, Sutrasthana, chapter 21, verse no. 21. 2nd edition, Varanasi; Chaukhamba Surbharati Prakashan;2019;404
Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. National Cholesterol Education Program (NCEP)Executive summary of the third report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA. 2001;285(19):2486–2497. Available from: https://www.nhlbi.nih.gov/guidelines/cholesterol
Baghel M, Rajagopala S, Developing Guidelines for Clinical Research Methodology in Ayurveda, WHO-DFC sponsored Project, Institute for Postgraduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar,2011;3.9
Singh H, Rai AK, Sharma D, Kumar S. Appraisal of obesity & related dyslipidemia w.s.r. Medoroga in Ayurveda. World J Pharm Res. 2017;6(8):445–54. Available from: https://www.wjpr.net/archive_show/2017/VOLUME%206%2C%20AUGUST%20ISSUE%208
Dongare D, Raut T. A critical review: probable mode of action of Chitrakadi Vati. World J Pharm Res. 2023;12(5):2284–2289. doi:10.20959/wjpr20235-258
Available from: https://wjpr.s3.ap-south 1.amazonaws.com/article_issue/6fbc5bea969496e54a649d0534f61a6b.pdf
Tripathi B (editor). Astanga Hridayam of Srimadvagbhata, Sutrasthana, chapter 2, verse no. 15. Reprint edition 2022, Delhi; Chaukhamba Sanskrita Pratishthan;2022;32
Govind Das Sen (editor). Bhaishajya Ratnavali, Netra Roga Adhikara; Trifaladi Ghrita, chapter 64, verse no.241-48. Edition 2011, Varanasi: Chaukhambha Surbharati Prakashan;2010;100913. Shastry JLN, editor. Dravya Guna Vignana. Part II, Chaukhambha Orientalia;Delhi; 2009;120.
Database on medicinal plants used in Ayurveda. Vol. 5. New Delhi: Central Council for Research in Ayurveda and Siddha (CCRAS), Ministry of AYUSH, Government of India; 2008; 89.
Sparshdeep EM, Nayak RP, Kavana GV, Rai M. Evaluation of hypolipidemic effect of Tinospora cordifolia in cholesterol diet induced hyperlipidemia in rats. International Journal of Basic and Clinical Pharmacology. 2016 July-Aug;5(4):1286-92. Available from: https://api.semanticscholar.org/CorpusID:78150621
Sharma G (Editor). Sharangdhar Samhita, Madhyam Khanda, chapter.2, verse no.75. Reprint edition 2013. Varanasi; Chaukhambha Krishnadas Academy; 2013;154
Kumar V. A critical review of Phaltrikadi Kwath w.s.r. to liver disorders. World Journal of Pharmaceutical and Medical Research. 2017;3(6):100–105. Available from: https://www.wjpmr.com/admin/assets/article_issue/23062017/1498810806.pdf
Saravanan S, Srikumar R, Manikandan S, Parthasarathy N, Devi R. Hypolipidemic effect of Triphala in experimentally induced hypercholesteremic rats. The Pharmaceutical Society of Japan. 2007;127(2):385-388. Available from: https://doi.org/10.1248/yakushi.127.38520.
Shankar MP, editor. Bhavaprakasha Nighantu of Bhavamishra, Haritakyadi Varga, chapter77, verse 221, 1st ed., Varanasi; Chaukhambha Bharati Academy; 2009; 267
Deepak BSR, Jadhav L, Girish KJ, Narayana P. Randomized controlled, open labeled study of a herbal preparation, lekhaneeya mahakashaya ghanavati in dyslipidemia patients, J Ayurveda Holist Med. 2015;3(4):1–23. JAHM [Internet]. 2021Apr.15 [cited 2026Jun.13];3(4). Available from: https://jahm.co.in/index.php/jahm/article/view/259
Additional Files
Published
How to Cite
Issue
Section
License
Copyright (c) 2026 Shravani U Mahajan, Digvijay Patil, Dhananjay Patel, Mandip Goyal
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Authors retain the copyright of their work and grant the Journal of Ayurveda and Holistic Medicine (JAHM) the right of first publication. All published articles are licensed under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) license, which permits non-commercial sharing, use, distribution, and adaptation with proper attribution and the same license terms.
JAHM ensures free, irrevocable, worldwide access to its content. Users may copy, distribute, display, and share published works for non-commercial purposes with appropriate credit to the author(s) and the journal. Limited printed copies for personal, non-commercial use are allowed under the same license.
If a submission is not accepted for publication, the author(s) will be notified.
By submitting, authors confirm that the work is original, that all listed authors have contributed and approved it, and that it does not infringe any third-party rights or duplicate work submitted elsewhere.
