Narrative Review on Anti-inflammatory Activity of Chloroxylon swietenia DC: Bridging Traditional Claims with Scientific Evidence
DOI:
https://doi.org/10.70066/jahm.v14i4.2605Keywords:
Ayurveda, Analgesic, Medicinal plants, Phytochemical, Ethnomedicine, East Indian satinwoodAbstract
Background: Chloroxylon swietenia DC (CS) or Bherra (East Indian Satinwood) is a traditional medicinal plant used in the south-eastern part of India. Different parts of this medium -sized deciduous tree, such as leaves, bark and fruits, have been used in folklore medicine to treat pain and inflammatory diseases. In spite of its many ethnomedicinal applications, strong scientific evidences still limited.
Objective: The purpose of this review is to evaluate the anti-inflammatory activity of CS extracts, along with the phytoconstituents involved in this activity.
Materials and Methods: The relevant information was gathered from classical Ayurvedic texts such as Dravyaguna vijnana by P. V. Sharma and standard reference books like Indian Medicinal Plant and Wealth of India. Also, the electronic databases, including PubMed, Science Direct, Google Scholar and IMPPAT 2.0, were searched to compile scientific work related to phytochemical and pharmacological activities.
Results: Phytochemical studies indicate that CS extracts contain a wide range of bioactive compounds, which may be responsible for a dose-dependent anti-inflammatory effect in various experimental models.
Discussion: The anti-inflammatory effect of CS is due to the presence of bioactive components in CS extracts, which can be responsible for modulating key inflammatory pathways, including arachidonic acid through inhibition of lipoxygenase, cyclooxygenase and phospholipase enzymes. Also, it shows a good safety profile with no toxic effects at experimental doses.
Conclusion: Experimental and phytochemical profiles support the traditional claim and scientific validation of anti -inflammatory potential of CS. However, further research on isolation, standardization and multicentric clinical trials is essential to establish a potent anti-inflammatory drug.
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