EVALUATION OF THE EFFECT OF AN AYURVEDIC DIETARY FORMULATION (PANCHAKOLASIDDHAYAVAGU) IN REDUCING THE DISEASE ACTIVITY SCORE (DAS28 USING C‐REACTIVE PROTEIN) AMONG AMAVATA PATIENTS
DOI:
https://doi.org/10.70066/jahm.v6i1.371Keywords:
Panchakolasiddhayavagu, Disease Activity Score, DAS28, Amavata, rheumatoid arthritisAbstract
Background: Amavata, is one among the multiple joint disorders explained in Ayurvedic classics. Its pathology is
explained to be beginning with the sluggish functioning of the bio fire (agni) or the digestive capacity. The disease is
having high prevalence rate and is of crippling nature. Practically there is no effective proven intervention in popular
practice to break the chains in the pathogenesis by correcting the bio-fire. Hence it was a high time to develop such an
intervention with a therapeutic diet restricting all other medicine and food to check the pathogenesis and thereby the
disease activity. Objective: The study attempted to evaluate effect of an Ayurvedic dietary formulation,
Panchakolasiddhayavagu in reducing the disease activity by using the Disease Activity Score (DAS 28) using CRP,
among amavata patients. Materials and Methods: In this uncontrolled clinical trial 20 participants were selected.
Intervention was till the attainment of proper digestive capacity, the optimum functioning of bio fire or maximum up to 10
days. Panchakolasiddhayavagu prepared as per the classical reference was given in morning and evening restricting all
other food and medicine. Pain was assessed daily using Numerical Rating Scale. Disease activity score was used to assess
the symptomatic relief. Results: There was highly significant reduction in pain (p<0.001) and significant reduction in
disease activity (p<0.001). The intervention shows significant results in reducing the CRP levels (p<0.05). Conclusion:
Administration of the Ayurvedic dietary preparation, panchakolasiddhayavagu was highly effective in reducing the disease
activity score DAS28. It was highly effective in reducing the pain and maximum significant change is observed between
day 7 and day 8. It also helped to reduce the CRP levels significantly.
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