COMPARATIVE STUDY OF EFFICACY OF SHIVA GUGGULU AND ALAMBUSHADI GHAN VATI IN THE MANAGEMENT OF AMAVATA WITH SPECIAL REFERENCE TO RHEUMATOID ARTHRITIS

Abstract

Background- The clinical presentation of Amavata closely mimics with the special variety of Rheumatologic disorders
called rheumatoid arthritis (R.A.). Prevalence of RA is approx. 0.8 % of the population. Due to wide spectrum of disease,
much prevalence in the society and lack of effective medicine, the disease had been chosen for the study. Aim- To
compare the efficacy of “Shiva Guggulu” and “Alambushadi Ghan Vati” in the management of Amavata (R.A.). Settings
and Design: Single Centered, Open Labeled, Randomized Clinical Study. Methods and Material: 50 clinically diagnosed
patients of Amavata and who fulfilled the criteria of inclusion and willing to participate in trial were registered for present
clinical trial and divided into two groups by simple randomization method (Lottery method). Group A- 25 patients of
Amavata were administered ‘Shiva Guggulu’ 2 Tab (each Tab 500 mg.) thrice in a day with lukewarm water, after meal for
30 days Group B- 25 patients of Amavata were administered ‘Alambushadi Ghan Vati’ 2 Tab (each Tab 500 mg) thrice in
a day, with lukewarm water, after meal for 30 days. Statistical analysis used: In Stat Graph Pad 3 Software was used for
statistical analysis. For Nonparametric data Wilcoxon matched-pairs signed ranks test while for Parametric data Paired‘t’
Test and for Intergroup comparison, Mann-Whitney Test & Unpaired ‘t’ Test were used. Conclusion: On comparing the
effect of two therapies it can be concluded that Group B (Alambushadi Ghana Vati) provided better relief
statistically than Group A (Shiva Guggulu) in most of the sign and symptom of the disease. It also considerably
prevents the relapse.